2018/01/02 by Mohammed I. El–Gamal, Shahad K. Al-Ameen, Dania M. Al-Koumi +3 · 1 citation
Immunology and Microbiology · Neuroscience · #Immune cells in cancer #Immune Response and Inflammation #Neuroinflammation and Neurodegeneration Mechanisms
paper · doi:10.1021/acs.jmedchem.7b00873
openalex publication_date 2018/01/02 · openalex created_date 2018/01/12 · openalex updated_date 2026/07/15
Colony stimulation factor-1 receptor (CSF-1R), which is also known as FMS kinase, plays an important role in initiating inflammatory, cancer, and bone disorders when it is overstimulated by its ligand, CSF-1. Innate immunity, as well as macrophage differentiation and survival, are regulated by the stimulation of the CSF-1R. Another ligand, interlukin-34 (IL-34), was recently reported to activate the CSF-1R receptor in a different manner. The relationship between CSF-1R and microglia has been reviewed. Both CSF-1 antibodies and small molecule CSF-1R kinase inhibitors have now been tested in animal models and in humans. In this Perspective, we discuss the role of CSF-1 and IL-34 in producing cancer, bone disorders, and inflammation. We also review the newly discovered and improved small molecule kinase inhibitors and monoclonal antibodies that have shown potent activity toward CSF-1R, reported from 2012 until 2017.