2010/03/18 by Dawn A. Lowe, Kristen A. Baltgalvis, Sarah M. Greising · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Anatomy #Biology #Endocrinology #Estrogen #Estrogen receptor #Exercise and Physiological Responses #Hormonal and reproductive studies #Internal medicine #Mechanism (biology) #Medicine #Muscle metabolism and nutrition #Muscle strength #Muscle weakness #Physiology #Testosterone (patch) #Weakness
paper · doi:10.1097/jes.0b013e3181d496bc
openalex publication_date 2010/03/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
In Brief Muscle weakness ensues when serum testosterone declines with age in men. Testosterone's female counterpart, estrogen, also has been implicated in age-related strength loss, but these results are less conclusive. Our working hypothesis is that estrogens do benefit muscle strength, and that the underlying mechanism involves estrogen receptors to improve muscle quality more so than quantity. Estrogen benefits strength by improving myosin function and muscle quality, and does so theoretically via estrogen receptors.