2017/07/06 by Rashi Minocha, Diona L. Damian, Gary M. Halliday · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Skin Protection and Aging #melanin and skin pigmentation #Photodynamic Therapy Research Studies
paper · pdf · doi:10.1111/phpp.12328
openalex publication_date 2017/07/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Summary Ultraviolet radiation ( UVR ) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8‐oxo‐7‐hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR , propagate carcinogenesis. Nicotinamide (Vitamin B 3 ) enhances DNA repair, modulates the inflammatory environment produced by UVR , and reduces UV ‐induced immunosuppression. As nicotinamide reduces the incidence of actinic keratoses and nonmelanoma skin cancers in high‐risk individuals and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high‐risk populations.