Alzheimer's Disease

2010/01/27 by Henry Querfurth, Frank M. LaFerla · 3 citations
Medicine · Neuroscience · #Alzheimer's disease #Alzheimer's disease research and treatments #Bioinformatics #Biology #Cholinesterase and Neurodegenerative Diseases #Cognition #Disease #Internal medicine #Mechanism (biology) #Medicine #Neuroscience #Oxidative damage #Oxidative stress #Pathology #Psychiatry #Tryptophan and brain disorders

paper · doi:10.1056/nejmra0909142

openalex publication_date 2010/01/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/02

Abstract

This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism of the disease and ties them together using the current understanding of the basis of the loss of cognition: the accumulation of misfolded proteins, which cause oxidative and inflammatory damage to the brain and, ultimately, synaptic dysfunction.

Citations

• Oxidative Damage Is the Earliest Event in Alzheimer Disease
• Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease
• Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
• Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
• Neurodegenerative Tauopathies

Cited by

• Amyloid Imaging: Poised for Integration into Medical Practice
• Postoperative cognitive dysfunction, Alzheimer's disease, and anesthesia
• Neuron [wikipedia]

Related

• Molecular mechanisms of neurodegeneration in Alzheimer's disease
• Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment
• Amyloid β-Protein Assembly and Alzheimer Disease
• Aging and Alzheimer's disease pathology
• The many roads to dementia: a systems view of Alzheimer's disease