2003/01/01 by N. H. C. Salmon Hillbertz, Magnus Isaksson, Elinor K. Karlsson +12 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Fibroblast Growth Factor Research #Genetic and rare skin diseases. #Hedgehog Signaling Pathway Studies #Teratomas and Epidermoid Cysts
paper · doi:10.1038/ng.2007.4
openalex publication_date 2003/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/04/28
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.