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The Rational Design of LRRK2 Inhibitors for Parkinson's Disease

2013/07/09 by Marco Piastra, Nadya Yousef, Roselyne Brat +4 · 1 citation
Agricultural and Biological Sciences · Medicine · Neuroscience · Physics and Astronomy · #Atomic and Subatomic Physics Research #Fungal Plant Pathogen Control #Nuclear Receptors and Signaling #Parkinson's Disease Mechanisms and Treatments #Pleural and Pulmonary Diseases #Ultrasound in Clinical Applications

paper · doi:10.1016/s0378-3782(14)50011-4

openalex publication_date 2013/07/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Meconium aspiration syndrome (MAS) is a rare and life-threatening neonatal lung injury induced by meconium in the lung and airways. Lung ultrasound (LUS) is a quick, easy and cheap imaging technique that is increasingly being used in critical care settings, also for newborns. In this paper we describe ultrasound findings in MAS. Six patients with MAS of variable severity were examined by LUS during the first hours of life. Chest X-rays were used as reference. The following dynamic LUS signs were seen in all patients: (1) B-pattern (interstitial) coalescent or sparse; (2) consolidations; (3) atelectasis; (4) bronchograms. No pattern was observed for the distribution of signs in lung areas, although the signs varied with time, probably due to the changing localisation of meconium in the lungs. LUS images corresponded well with X-ray findings. In conclusion, we provide the first formal description of LUS findings in neonates with MAS. LUS is a useful and promising tool in the diagnosis and management of MAS, providing real-time bedside imaging, with the additional potential benefit of limiting radiation exposure in sick neonates.

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