2012/01/01 by Amit Chopra, Susannah J. Tye, Kendall H. Lee +7 · 1 citation
Medicine · Neuroscience · #Neurological disorders and treatments #Parkinson's Disease Mechanisms and Treatments #Genetic Neurodegenerative Diseases
paper · doi:10.1176/appi.neuropsych.10070109
openalex publication_date 2012/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Deep brain stimulation (DBS) is a novel and effective surgical intervention for refractory Parkinson's disease (PD). The authors review the current literature to identify the clinical correlates associated with subthalamic nucleus (STN) DBS-induced hypomania/mania in PD patients. Ventromedial electrode placement has been most consistently implicated in the induction of STN DBS-induced mania. There is some evidence of symptom amelioration when electrode placement is switched to a more dorsolateral contact. Additional clinical correlates may include unipolar stimulation, higher voltage (>3 V), male sex, and/or early-onset PD. STN DBS-induced psychiatric adverse events emphasize the need for comprehensive psychiatric presurgical evaluation and follow-up in PD patients. Animal studies and prospective clinical research, combined with advanced neuroimaging techniques, are needed to identify clinical correlates and underlying neurobiological mechanisms of STN DBS-induced mania. Such working models would serve to further our understanding of the neurobiological underpinnings of mania and contribute valuable new insight toward development of future DBS mood-stabilization therapies.