How Mutational Networks Shape Evolution: Lessons from RNA Models

2007/07/31 by Matthew C. Cowperthwaite, Lauren Ancel Meyers · 3 citations
Biochemistry, Genetics and Molecular Biology · #RNA and protein synthesis mechanisms #Evolution and Genetic Dynamics #Genomics and Phylogenetic Studies

paper · doi:10.1146/annurev.ecolsys.38.091206.095507

openalex publication_date 2007/07/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

Recent advances in molecular biology and computation have enabled evolutionary biologists to develop models that explicitly capture molecular structure. By including complex and realistic maps from genotypes to phenotypes, such models are yielding important new insights into evolutionary processes. In particular, computer simulations of evolving RNA structure have inspired a new conceptual framework for thinking about patterns of mutational connectivity and general theories about the nature of evolutionary transitions, the evolutionary ascent of nonoptimal phenotypes, and the origins of mutational robustness and modular structures. Here, we describe this class of RNA models and review the major conceptual contributions they have made to evolutionary biology.

Citations

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Cited by

• EVOLUTION OF EVOLVABILITY IN A DEVELOPMENTAL MODEL
• Pathways to extinction: beyond the error threshold
• Mutation [wikipedia]