2017/07/12 by Diarmaid Hughes, Dan I. Andersson · 1 citation
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Evolution and Genetic Dynamics #Antibiotic Resistance in Bacteria #Pharmacogenetics and Drug Metabolism
paper · doi:10.1146/annurev-micro-090816-093813
openalex publication_date 2017/07/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
The ability to predict the evolutionary trajectories of antibiotic resistance would be of great value in tailoring dosing regimens of antibiotics so as to maximize the duration of their usefulness. Useful prediction of resistance evolution requires information about (a) the mutation supply rate, (b) the level of resistance conferred by the resistance mechanism, (c) the fitness of the antibiotic-resistant mutant bacteria as a function of drug concentration, and (d) the strength of selective pressures. In addition, processes including epistatic interactions and compensatory evolution, coselection of drug resistances, and population bottlenecks and clonal interference can strongly influence resistance evolution and thereby complicate attempts at prediction. Currently, the very limited quantitative data on most of these parameters severely limit attempts to accurately predict trajectories of resistance evolution.