Mitochondrial Fission, Fusion, and Stress

2012/08/30 by Richard J. Youle, Alexander M. van der Bliek · 5 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Mitochondrial Function and Pathology #Autophagy in Disease and Therapy #Metabolism and Genetic Disorders

paper · doi:10.1126/science.1219855

openalex publication_date 2012/08/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by mixing the contents of partially damaged mitochondria as a form of complementation. Fission is needed to create new mitochondria, but it also contributes to quality control by enabling the removal of damaged mitochondria and can facilitate apoptosis during high levels of cellular stress. Disruptions in these processes affect normal development, and they have been implicated in neurodegenerative diseases, such as Parkinson's.

Citations

• Recent advances into the understanding of mitochondrial fission
• Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
• Mitochondria, Oxidants, and Aging
• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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• Mitochondria [wikipedia]

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