PROTEIN IMPORT INTO MITOCHONDRIA

1997/06/01 by Walter Neupert · 8 citations
Biochemistry, Genetics and Molecular Biology · #Mitochondrial Function and Pathology #Cell death mechanisms and regulation #ATP Synthase and ATPases Research

paper · doi:10.1146/annurev.biochem.66.1.863

openalex publication_date 1997/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/24

Abstract

Mitochondria import many hundreds of different proteins that are encoded by nuclear genes. These proteins are targeted to the mitochondria, translocated through the mitochondrial membranes, and sorted to the different mitochondrial subcompartments. Separate translocases in the mitochondrial outer membrane (TOM complex) and in the inner membrane (TIM complex) facilitate recognition of preproteins and transport across the two membranes. Factors in the cytosol assist in targeting of preproteins. Protein components in the matrix partake in energetically driving translocation in a reaction that depends on the membrane potential and matrix-ATP. Molecular chaperones in the matrix exert multiple functions in translocation, sorting, folding, and assembly of newly imported proteins.

Citations

• Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase

Cited by

• Mitochondrial Evolution
• On the origin of mitochondria: a genomics perspective
• Protein transport into mitochondria
• Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective
• Biogenesis of Tim Proteins of the Mitochondrial Carrier Import Pathway: Differential Targeting Mechanisms and Crossing Over with the Main Import Pathway
• Transport of proteins into mitochondria
• Protein translocation into mitochondria: the role of TIM complexes
• Mitochondria [wikipedia]