TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS

2003/01/01 by Peter D. Keightley, Michael Lynch · 2 citations
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Evolution and Genetic Dynamics #Genetic diversity and population structure #Plant and animal studies

paper · doi:10.1554/0014-3820(2003)057[0683:tarmom]2.0.co;2

openalex publication_date 2003/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

Citations

• Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegans
• New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster

Cited by

• The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus
• Mutation [wikipedia]