2019/07/04 by Karl Landheer, Rolf F. Schulte, Michael Treacy +2 · 2 citations
Medicine · Chemistry · Physics and Astronomy · #Advanced MRI Techniques and Applications #Advanced NMR Techniques and Applications #NMR spectroscopy and applications
paper · doi:10.1002/jmri.26846
openalex publication_date 2019/07/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
This article reviews the most commonly used modern sequences designed to confront the two major challenges of in vivo magnetic resonance spectroscopy (MRS): spatial localization and metabolic specificity. The purpose of this review article is to provide a deeper and clearer understanding of the underlying mechanisms by which all modern MRS sequences operate. A descriptive explanation, consistent pulse sequence diagram, and theoretical concepts of the measured signal are given for five spatial localization sequences and three modules designed to increase metabolic specificity. Cross‐sequence comparisons, including potential modifications for estimating quantitative measures like spin‐lattice relaxation time T 1 , spin‐spin relaxation time T 2 , and diffusion coefficients are briefly discussed. Level of Evidence: 5 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2020;51:1008–1029.