2010/03/01 by Bronwen Martin, Sunggoan Ji, Stuart Maudsley +1 · 1 citation
Medicine · Neuroscience · #Adipose Tissue and Metabolism #Adipokines, Inflammation, and Metabolic Diseases #Stress Responses and Cortisol
paper · doi:10.1073/pnas.0912955107
openalex publication_date 2010/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects.