Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

2013/12/15 by Hyung‐Jun Kim, Hyung-Jun Kim, Alya R Raphael +15 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Amyotrophic Lateral Sclerosis Research #Neurogenetic and Muscular Disorders Research #RNA Research and Splicing

paper · doi:10.1038/ng.2853

crossref issued 2013/12/15 · crossref published 2013/12/15 · crossref published-online 2013/12/15 · openalex publication_date 2013/12/15 · crossref created 2013/12/15 · crossref published-print 2014/02/01 · crossref deposited 2023/05/18 · openalex created_date 2025/10/10 · crossref indexed 2026/07/24 · openalex updated_date 2026/08/01

Citations

• Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
• ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
• Translation suppression promotes stress granule formation and cell survival in response to cold shock
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
• TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

Cited by

• Model organism [wikipedia]