2009/10/01 by Cynthia S. Goldsmith, Sara Miller · 1 citation
Medicine · Agricultural and Biological Sciences · #Viral gastroenteritis research and epidemiology #Viral Infections and Immunology Research #Animal Virus Infections Studies
paper · doi:10.1128/cmr.00027-09
openalex publication_date 2009/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Electron microscopy, considered by some to be an old technique, is still on the forefront of both clinical viral diagnoses and viral ultrastructure and pathogenesis studies. In the diagnostic setting, it is particularly valuable in the surveillance of emerging diseases and potential bioterrorism viruses. In the research arena, modalities such as immunoelectron microscopy, cryo-electron microscopy, and electron tomography have demonstrated how viral structural components fit together, attach to cells, assimilate during replication, and associate with the cellular machinery during replication and egression. These studies provide information for treatment and vaccine strategies.