2009/02/01 by Chiranjib Chakraborty, Chi Chien Hsü, Zhi Wen +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Zebrafish Biomedical Research Applications #CRISPR and Genetic Engineering #Pluripotent Stem Cells Research
paper · doi:10.2174/138920009787522197
openalex publication_date 2009/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
In last few years, the use of zebrafish (Danio rerio) in scientific research is growing very rapidly. Initially, it was a popular as a model of vertebrate development because zebrafish embryos are transparent and also develop rapidly. Presently, the research using zebrafish is expanding into other areas such as pharmacology, clinical research as a diseases model and interestingly in drug discovery. The use of zebrafish in pharmaceutical research and discovery and drug development is mainly screening of lead compounds, target identification, target validation, morpholino oligonucleotide screens, assay development for drug discovery, physiology based drug discovery, quantitative structure-activity relationship (QSAR) and structure -activity relationships (SAR) study and drug toxicity study. In this paper, we have described properly all the areas of drug discovery where zebrafish is used as a tool. We are hopeful that the use of these techniques or methods will make the zebrafish a prominent model in drug discovery and development research in the forthcoming years.