2019/09/01 by Kirill V. Korneev · 82 citations
Engineering · Immunology and Microbiology · Medicine · Neuroscience · #Adipokines, Inflammation, and Metabolic Diseases #Biology #Computational biology #Computer science #Engineering #Immune Response and Inflammation #Immunology #Inflammation #Intensive care medicine #Internal medicine #Medicine #Neuroscience #Sepsis #Sepsis Diagnosis and Treatment #Septic shock #Shock (circulatory) #Systems engineering #Task (project management)
paper · pdf · doi:10.1134/s0026893319050108
published in Molecular Biology 53(5), 704-717 (Pleiades Publishing)
openalex publication_date 2019/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Abstract An extensive network of regulation of systemic inflammation makes development of a reproducible experimental model of sepsis a complex task. There is no single mouse model that can capture all clinical aspects of this complicated pathology. However, a combination of existing approaches can go a long way towards analysis of specific mechanisms of sepsis development and to the design of novel therapeutic approaches. This review describes the popular mouse models of sepsis and septic shock, as well as their limitations and development strategies.