2013/09/01 by Ryan S. Pawell, David W. Inglis, Tracie Barber +1 · 2 citations
Engineering · #Biomedical engineering #Composite material #Computer science #Electrowetting and Microfluidic Technologies #Engineering #Fabrication #Materials science #Microfluidic and Bio-sensing Technologies #Microfluidic and Capillary Electrophoresis Applications #Microfluidics #Mold #Nanotechnology #Wetting
paper · pdf · doi:10.1063/1.4821315
openalex publication_date 2013/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
Deterministic lateral displacement (DLD) is a microfluidic size-based particle separation or filter technology with applications in cell separation and enrichment. Currently, there are no cost-effective manufacturing methods for this promising microfluidic technology. In this fabrication paper, however, we develop a simple, yet robust protocol for thermoplastic DLD devices using regulatory-approved materials and biocompatible methods. The final standalone device allowed for volumetric flow rates of 660 μl min(-1) while reducing the manufacturing time to <1 h. Optical profilometry and image analysis were employed to assess manufacturing accuracy and precision; the average replicated post height was 0.48% less than the average post height on the master mold and the average replicated array pitch was 1.1% less than the original design with replicated posts heights of 62.1 ± 5.1 μm (mean ± 6 standard deviations) and replicated array pitches of 35.6 ± 0.31 μm.