1974/06/01 by Ronald W. Hart, R. B. Setlow · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Carcinogens and Genotoxicity Assessment #DNA Repair Mechanisms #Radiation Therapy and Dosimetry
paper · doi:10.1073/pnas.71.6.2169
openalex publication_date 1974/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.