Loop-closure principles in protein folding

2007/09/21 by Thomas R. Weikl, Weikl, Thomas R.
Biochemistry, Genetics and Molecular Biology · Materials Science · #Biomolecules (q-bio.BM) #Enzyme Structure and Function #FOS: Biological sciences #Glycosylation and Glycoproteins Research #Protein Structure and Dynamics

paper · pdf · doi:10.48550/arxiv.0709.3388

openalex publication_date 2007/09/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Simple theoretical concepts and models have been helpful to understand the folding rates and routes of single-domain proteins. As reviewed in this article, a physical principle that appears to underly these models is loop closure.

Citations

• Native geometry and the dynamics of protein folding
• Φ values in protein-folding kinetics have energetic and structural components
• Protein folding: Defining a “standard” set of experimental conditions and a preliminary kinetic data set of two‐state proteins

Related

• Loop-closure events during protein folding: Rationalizing the shape of Phi-value distributions
• Decoding How Proteins Fold
• Protein Collapse is Encoded in the Folded State Architecture
• How Do Proteins Fold?
• Toward a Theory on the Stability of Protein Folding: Challenges for Folding Models