Integrin signalling at a glance

2008/12/31 by David S. Harburger, David A. Calderwood, David Calderwood · 898 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Caveolin-1 and cellular processes #Cell Adhesion Molecules Research #Cell biology #Computational biology #Integrin #Receptor #Receptor Mechanisms and Signaling #Signalling

paper · open access · doi:10.1242/jcs.018093

published in Journal of Cell Science 122(2), 159-163 (The Company of Biologists)

openalex publication_date 2008/12/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Integrins are a major family of cell-surface-adhesion receptors that are expressed in all metazoans. They are heterodimers of noncovalently associated α and β subunits, each of which is a single-pass type I transmembrane protein ([Humphries et al., 2006][1]; [Hynes, 2002][2]). The specific binding

Citations

• Structure of the Integrin β3 Transmembrane Segment in Phospholipid Bicelles and Detergent Micelles

Cited by

• The extracellular matrix at a glance
• Engineering biocompatible implant surfaces
• The Mammalian Blood-Testis Barrier: Its Biology and Regulation
• Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering
• Load-dependent RGD-context sensing via αV-class integrin reprograms cellular adhesion and mechanics within seconds
• Low‐intensity ultrasound induces angiogenesis by activating endothelial integrin signaling in male mice
• Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects
• Bacterial invasion of epithelial cells and spreading in periodontal tissue. [europepmc]
• The tail of integrin activation. [europepmc]
• Molecular architecture and function of matrix adhesions. [europepmc]
• Role of shear stress and stretch in vascular mechanobiology. [europepmc]
• Filopodia and adhesion in cancer cell motility. [europepmc]
• Extracellular matrix regulation in the muscle satellite cell niche. [europepmc]
• Investigating cell mechanics with atomic force microscopy. [europepmc]
• Tenascin-C and integrins in cancer. [europepmc]
• Emerging roles of focal adhesion kinase in cancer. [europepmc]
• Regulation of integrin-mediated adhesions. [europepmc]
• Integrin endosomal signalling suppresses anoikis. [europepmc]
• Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells. [europepmc]
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance. [europepmc]
• β 2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function. [europepmc]
• Role of Extracellular Matrix in Development and Cancer Progression. [europepmc]
• Integrins, CAFs and Mechanical Forces in the Progression of Cancer. [europepmc]
• Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. [europepmc]
• Molecular mechanosensors in osteocytes. [europepmc]
• RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field. [europepmc]
• Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response. [europepmc]
• 3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages. [europepmc]
• The Functional Role of Extracellular Matrix Proteins in Cancer. [europepmc]
• Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression. [europepmc]
• Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets. [europepmc]
• Mechanisms of assembly and remodelling of the extracellular matrix. [europepmc]

Related

• Integrin-dependent phagocytosis – spreading from microadhesion to new concepts
• Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
• Mechanisms and Consequences of Affinity Modulation of Integrin αVβ3 Detected with a Novel Patch-engineered Monovalent Ligand
• Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway
• Load-dependent RGD-context sensing via αV-class integrin reprograms cellular adhesion and mechanics within seconds