Mitochondrial dynamics in neuronal injury, development and plasticity

2017/02/03 by Kyle H. Flippo, Stefan Strack · 255 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #ATP Synthase and ATPases Research #Biology #Cell biology #Dynamics (music) #Metabolism and Genetic Disorders #Mitochondrial Function and Pathology #Neuroplasticity #Neuroscience #Plasticity

paper · open access · doi:10.1242/jcs.171017

published in Journal of Cell Science 130(4), 671-681 (The Company of Biologists)

openalex publication_date 2017/02/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

buffering, neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis and intermediate metabolism. Mitochondrial dynamics, a collective term for the processes of mitochondrial fission, fusion and transport, governs mitochondrial function and localization within the cell. Correct balance of mitochondrial dynamics is especially important in neurons as mutations in fission and fusion enzymes cause peripheral neuropathies and impaired development of the nervous system in humans. Regulation of mitochondrial dynamics is partly accomplished through post-translational modification of mitochondrial fission and fusion enzymes, in turn influencing mitochondrial bioenergetics and transport. The importance of post-translational regulation is highlighted by numerous neurodegenerative disorders associated with post-translational modification of the mitochondrial fission enzyme Drp1. Not surprisingly, mitochondrial dynamics also play an important physiological role in the development of the nervous system and synaptic plasticity. Here, we highlight recent findings underlying the mechanisms and regulation of mitochondrial dynamics in relation to neurological disease, as well as the development and plasticity of the nervous system.

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