AP-1 subunits: quarrel and harmony among siblings

2004/11/24 by Jochen Hess, Jochen Heß, Peter Angel +2 · 1,303 citations
Biochemistry, Genetics and Molecular Biology · #Biology #Carcinogenesis #Cell biology #Cell death mechanisms and regulation #Cell growth #Gene #Genetics #Melanoma and MAPK Pathways #Neoplastic transformation #Retinoids in leukemia and cellular processes #Signal transduction #Stimulus (psychology) #Transcription factor

paper · doi:10.1242/jcs.01589

published in Journal of Cell Science 117(25), 5965-5973 (The Company of Biologists)

openalex publication_date 2004/11/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It mediates gene regulation in response to a plethora of physiological and pathological stimuli, including cytokines, growth factors, stress signals, bacterial and viral infections, as well as oncogenic stimuli. Studies in genetically modified mice and cells have highlighted a crucial role for AP-1 in a variety of cellular events involved in normal development or neoplastic transformation causing cancer. However, emerging evidence indicates that the contribution of AP-1 to determination of cell fates critically depends on the relative abundance of AP-1 subunits, the composition of AP-1 dimers, the quality of stimulus, the cell type and the cellular environment. Therefore, AP-1-mediated regulation of processes such as proliferation, differentiation, apoptosis and transformation should be considered within the context of a complex dynamic network of signalling pathways and other nuclear factors that respond simultaneously.

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