Structure and functions of nucleolin

1999/03/15 by Hervé Ginisty, Hélène Sicard, Benoit Roger +2 · 28 citations
Biochemistry, Genetics and Molecular Biology · #RNA modifications and cancer #RNA and protein synthesis mechanisms #Genomics and Chromatin Dynamics

paper · doi:10.1242/jcs.112.6.761

Abstract

Nucleolin is an abundant protein of the nucleolus. Nucleolar proteins structurally related to nucleolin are found in organisms ranging from yeast to plants and mammals. The association of several structural domains in nucleolin allows the interaction of nucleolin with different proteins and RNA sequences. Nucleolin has been implicated in chromatin structure, rDNA transcription, rRNA maturation, ribosome assembly and nucleo-cytoplasmic transport. Studies of nucleolin over the last 25 years have revealed a fascinating role for nucleolin in ribosome biogenesis. The involvement of nucleolin at multiple steps of this biosynthetic pathway suggests that it could play a key role in this highly integrated process.

Cited by

• Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis
• Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation
• Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES‐bound complexes
• Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis. [europepmc]
• Localization to the nucleolus is a common feature of coronavirus nucleoproteins, and the protein may disrupt host cell division. [europepmc]
• Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes. [europepmc]
• Modulation of RNA editing by functional nucleolar sequestration of ADAR2. [europepmc]
• Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. [europepmc]
• Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication. [europepmc]
• Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells. [europepmc]
• Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. [europepmc]
• Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. [europepmc]
• A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism. [europepmc]
• The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity. [europepmc]
• Targeting MYC Expression through G-Quadruplexes. [europepmc]
• Competitive regulation of nucleolin expression by HuR and miR-494. [europepmc]
• Direct observation of nanoparticle-cancer cell nucleus interactions. [europepmc]
• Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells. [europepmc]
• Nucleolar stress with and without p53. [europepmc]
• Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications. [europepmc]
• Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome. [europepmc]
• Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers. [europepmc]
• Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease. [europepmc]
• C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. [europepmc]
• Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid⁻Protein Interaction. [europepmc]
• A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. [europepmc]
• G4-quadruplex-binding proteins: review and insights into selectivity. [europepmc]
• Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications. [europepmc]

Related

• Emerging roles for the nucleolus in development and stem cells
• The dual nature of the nucleolus
• Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis
• Profiling of i-motif-binding proteins reveals functional roles of nucleolin in regulation of high-order DNA structures
• Bacterial nucleoid is a riddle wrapped in a mystery inside an enigma