IQGAP1: a key regulator of adhesion and migration

2005/05/12 by Jun Noritake, Takashi Watanabe, Kazumasa Sato +2 · 25 citations
Biochemistry, Genetics and Molecular Biology · #Cellular Mechanics and Interactions #Microtubule and mitosis dynamics #Wnt/β-catenin signaling in development and cancer

paper · doi:10.1242/jcs.02379

Abstract

The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in tissue development and tumor metastasis. Polarized cell migration, another key event, is a tightly regulated process that occurs during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively. It captures and stabilizes microtubules through the microtubule-binding protein CLIP-170 near the cell cortex, leading to establishment of polarized cell morphology and directional cell migration. Furthermore, Rac1 and Cdc42 link the adenomatous polyposis coli (APC) protein to actin filaments through IQGAP1 at the leading edge and thereby regulate polarization and directional migration.

Cited by

• IQGAP1 modulates activation of B-Raf. [europepmc]
• N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. [europepmc]
• Compartmentalization of redox signaling through NADPH oxidase-derived ROS. [europepmc]
• Protein scaffolds in MAP kinase signalling. [europepmc]
• ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway. [europepmc]
• IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. [europepmc]
• Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells. [europepmc]
• RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. [europepmc]
• IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. [europepmc]
• IQGAP1 regulates NR2A signaling, spine density, and cognitive processes. [europepmc]
• The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. [europepmc]
• Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. [europepmc]
• IQGAP1 and its binding proteins control diverse biological functions. [europepmc]
• IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. [europepmc]
• Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress. [europepmc]
• The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. [europepmc]
• Quorum sensing communication between bacteria and human cells: signals, targets, and functions. [europepmc]
• Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. [europepmc]
• PIP kinases define PI4,5P₂signaling specificity by association with effectors. [europepmc]
• IQGAPs choreograph cellular signaling from the membrane to the nucleus. [europepmc]
• Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. [europepmc]
• A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles. [europepmc]
• Regulatory Networks of LncRNA MALAT-1 in Cancer. [europepmc]
• ATG9A protects the plasma membrane from programmed and incidental permeabilization. [europepmc]
• Navigating the ERK1/2 MAPK Cascade. [europepmc]

Related

• The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling
• The ARF GTPase regulatory network in collective invasion and metastasis
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• GTPase activating protein DLC1 spatio-temporally regulates Rho signaling