MOLECULARTHEORY OFHYDROPHOBICEFFECTS: “She is too mean to have her name repeated.”

2001/10/07 by Lawrence R. Pratt · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Physics and Astronomy · #Advanced Physical and Chemical Molecular Interactions #Aqueous solution #Chemical stability #Denaturation (fissile materials) #Lipid Membrane Structure and Behavior #Macromolecule #Protein Structure and Dynamics #Stability (learning theory) #Work (physics) #physics.bio-ph #physics.chem-ph #q-bio

paper · pdf · doi:10.1146/annurev.physchem.53.090401.093500

submitted to Ann. Rev. Phys. Chem., 31 pages, 245 references, 2 figures

arxiv created 2001/10/07 · openalex publication_date 2002/07/27 · arxiv updated 2015/06/26 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05

Abstract

This paper reviews the molecular theory of hydrophobic effects relevant to biomolecular structure and assembly in aqueous solution. Recent progress has resulted in simple, validated molecular statistical thermodynamic theories and clarification of confusing theories of decades ago. Current work is resolving effects of wider variations of thermodynamic state, e.g., pressure denaturation of soluble proteins, and more exotic questions such as effects of surface chemistry in treating stability of macromolecular structures in aqueous solution.

Citations

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