2019/02/14 by Juanjuan Zhao, Yongping Song, Delong Liu · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #CAR-T cell therapy research #CRISPR and Genetic Engineering #Virus-based gene therapy research
paper · pdf · doi:10.1186/s13045-019-0705-x
openalex publication_date 2019/02/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
The current treatment for pediatric acute lymphoblastic leukemia (ALL) is highly successful with high cure rate. However, the treatment of adult ALL remains a challenge, particularly for refractory and/or relapsed (R/R) ALL. The advent of new targeted agents, blinatumomab, inotuzumab ozogamycin, and chimeric antigen receptor (CAR) T cells, are changing the treatment paradigm for ALL. Tisagenlecleucel (kymriah, Novartis) is an autologous CD19-targeted CAR T cell product approved for treatment of R/R B cell ALL and lymphoma. In an attempt to reduce the relapse rate and treat those relapsed patients with antigen loss, donor-derived CAR T cells and CD19/CD22 dual-target CAR T cells are in clinical trials. Gene-edited "off-the-shelf" universal CAR T cells are also undergoing active clinical development. This review summarized new clinical trials and latest updates at the 2018 ASH Annual Meeting on CAR T therapy for ALL with a focus on dual-target CAR T and universal CAR T cell trials.