2016/04/29 by Didac Carmona‐Gutiérrez, Adam L. Hughes, Frank Madeo +1 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Autophagy in Disease and Therapy #Calcium signaling and nucleotide metabolism #Genetics, Aging, and Longevity in Model Organisms
paper · pdf · doi:10.1016/j.arr.2016.04.009
openalex publication_date 2016/04/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of cellular processes, including responses to nutrient availability and composition, stress resistance, programmed cell death, plasma membrane repair, development, and cell differentiation. In line with this pleiotropic importance for cellular and organismal life and death, lysosomal dysfunction is associated with many age-related pathologies like Parkinson's and Alzheimer's disease, as well as with a decline in lifespan. Conversely, targeting lysosomal functional capacity is emerging as a means to promote longevity. Here, we analyze the current knowledge on the prominent influence of lysosomes on aging-related processes, such as their executory and regulatory roles during general and selective macroautophagy, or their storage capacity for amino acids and ions. In addition, we review and discuss the roles of lysosomes as active players in the mechanisms underlying known lifespan-extending interventions like, for example, spermidine or rapamycin administration. In conclusion, this review aims at critically examining the nature and pliability of the different layers, in which lysosomes are involved as a control hub for aging and longevity.