2023/10/30 by Kowalec, Kaarina, Riel, Hayley, Safa, Mira +3
#Cardiovascular Diseases #Digestive System Diseases #Diseases #Endocrine System Diseases #Immune System Diseases #Medicine and Health Sciences #Mental and Social Health #Musculoskeletal Diseases #Neoplasms #Nervous System Diseases #Nutritional and Metabolic Diseases #Otorhinolaryngologic Diseases #Psychiatric and Mental Health #Skin and Connective Tissue Diseases
paper · doi:10.17605/osf.io/hk7a5
Comorbidities are common in MS, including depression, anxiety, and hypertension. Compared to people without MS, those with MS have an increased risk of many comorbidities. The precise reasons for this are unknown. Several possibilities exist including improved identification of comorbidities due to increased healthcare use. Other, more specific mechanisms also exist including shared risk factors, or due to one condition and/or its treatment causing another. Shared environmental and behavioral risk factors, such as smoking, and obesity increase the chance of comorbidities in MS and are evidenced by observational studies and Mendelian randomization methods. MS and comorbidities may share genetic architecture, as highlighted by positive genetic correlations between MS with amyotrophic lateral sclerosis and inflammatory bowel disease. Mendelian randomization studies have identified MS as playing a potential causal role in certain comorbidities, including towards lung cancer and cardiovascular diseases. As part of the SPRINT program, The goal of the present project is to perform a review of studies examining the etiology of MS comorbidities.