2020/07/15 by Arijit Mahapatra, Mahapatra, Arijit, Can Uysalel +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · #Biological Physics (physics.bio-ph) #FOS: Biological sciences #FOS: Physical sciences #Lipid Membrane Structure and Behavior #Molecular Junctions and Nanostructures #Nanopore and Nanochannel Transport Studies #Soft Condensed Matter (cond-mat.soft) #Subcellular Processes (q-bio.SC)
paper · pdf · doi:10.48550/arxiv.2007.07510
openalex publication_date 2020/07/15 · openalex created_date 2022/07/26 · openalex updated_date 2026/07/28
Membrane tubulation is a ubiquitous process that occurs both at the plasma\nmembrane and on the membranes of intracellular organelles. These tubulation\nevents are known to be mediated by forces applied on the membrane either due to\nmotor proteins, by polymerization of the cytoskeleton, or due to the\ninteractions between membrane proteins binding onto the membrane. The numerous\nexperimental observations of tube formation have been amply supported by\nmathematical modeling of the associated membrane mechanics and have provided\ninsights into the force-displacement relationships of membrane tubes. Recent\nadvances in quantitative biophysical measurements of membrane-protein\ninteractions and tubule formation have necessitated the need for advances in\nmodeling that will account for the interplay of multiple aspects of physics\nthat occur simultaneously. Here, we present a comprehensive review of\nexperimental observations of tubule formation and provide context from the\nframework of continuum modeling. Finally, we explore the scope for future\nresearch in this area with an emphasis on iterative modeling and experimental\nmeasurements that will enable us to expand our mechanistic understanding of\ntubulation processes in cells.\n