2019/12/10 by Sanjog Vilas Joshi, Joshi, Sanjog V., Pradeep R. Nair +1
Chemical Engineering · Chemistry · Engineering · #Analytical Chemistry and Sensors #Applied Physics (physics.app-ph) #Biological Physics (physics.bio-ph) #Electrochemical Analysis and Applications #Electrochemical sensors and biosensors #FOS: Physical sciences
paper · pdf · doi:10.48550/arxiv.1912.04544
openalex publication_date 2019/12/10 · openalex created_date 2022/07/26 · openalex updated_date 2026/07/28
Electrochemical biosensors and the related concept of redox detection at\nnanogap electrodes are increasingly explored for ultra-sensitive detection of\nbiomolecules. While experimental demonstrations have been encouraging, the\nassociated design and optimization of electrode geometry, beyond the simple\none-dimensional architectures, is inherently challenging from multiple aspects\nrelated to numerical complexity. Here we develop a facile simulation scheme to\naddress this challenge using well established electronic circuit analysis\ntechniques that are available as open source-ware. Based on this approach, we\nshow that electrode geometry, especially nano-structured redox electrodes on a\nplanar surface, has interesting implications on the detection limits and\nsettling time of electrochemical biosensors. The methodology we developed and\nthe insights obtained could be useful for electrode optimization for a wide\nvariety of problems ranging from biosensors to electrochemical storage.\n