2013/05/30 by Christian Wagner, C. Wagner, P. Steffen +2
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Physics and Astronomy · #Biochemistry #Biology #Biophysics #Blood groups and transfusion #Blood properties and coagulation #Cell biology #Chemistry #Clot formation #Erythrocyte Function and Pathophysiology #Erythrocyte aggregation #Fibrinogen #Immunology #Internal medicine #Medicine #Platelet #Platelet aggregation #Red Cell #Red blood cell #Surgery #Thrombus #cond-mat.soft #physics.bio-ph #q-bio.CB
paper · pdf · doi:10.1016/j.crhy.2013.04.004
published as Comptes Rendues en Physique 14, 459 (2013)
openalex publication_date 2013/05/30 · arxiv created 2013/10/05 · arxiv updated 2015/06/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Red blood cells are known to form aggregates in the form of rouleaux. This aggregation process is believed to be reversible, but there is still no full understanding on the adhesion mechanism. There are at least two competing models, based either on bridging or on depletion. We review recent experimental results on the single cell level and theoretical analyses of the depletion model and of the influence of the cell shape on the adhesion strength. Another important aggregation mechanism is caused by activation of platelets. This leads to clot formation which is life-saving in the case of wound healing, but also a major cause of death in the case of a thrombus induced stroke. We review historical and recent results on the participation of red blood cells in clot formation.