Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978/03/01 by Susumu Tonegawa, Allan M. Maxam, Richard Tizard +2 · 2 citations
Biochemistry, Genetics and Molecular Biology · #DNA and Nucleic Acid Chemistry #Genomics and Chromatin Dynamics #Glycosylation and Glycoproteins Research

paper · doi:10.1073/pnas.75.3.1485

openalex publication_date 1978/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

We have determined the sequence of the DNA of a germ-line gene for the variable region of a mouse immunoglobulin light chain, the VlambdaII gene. The sequence confirms that the variable region gene lies on the DNA separated from the constant region. Hypervariable region codons appear in the germ-line sequence. A sequence for the hydrophobic leader, 19 amino acids that are cleaved from the amino terminus of the protein, appears near, but not continuous with, the light chain structural sequence: most of the leader sequence is separated from the rest of the gene by 93 bases of untranslated DNA.

Citations

• Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.
• Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

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