Hepatitis C Virus, the E2 Envelope Protein, and α-Interferon Resistance

2000/03/03 by Karim Abid, Rafael Quadri, Francesco Negro · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Immunology and Microbiology · #RNA regulation and disease #Hepatitis C virus research #interferon and immune responses

paper · doi:10.1126/science.287.5458.1555a

openalex publication_date 2000/03/03 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/23

Abstract

Taylor et al . ([1][1]) showed that the hepatitis C virus (HCV) envelope protein E2 inhibits the activity of the interferon-inducible protein kinase PKR in cell systems. PKR is an antiviral protein that blocks protein synthesis by phosphorylating the translation initiation factor eIF2α ([2][2]).

Citations

• Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein
• Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways

Cited by

• Interferon [wikipedia]