2013/05/28 by Chinmaya Gupta, José Manuel López, William Ott +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · #q-bio.MN
paper · pdf · doi:10.1103/physrevlett.111.058104
arxiv created 2013/05/28 · arxiv updated 2015/06/16
Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner.