1970/09/01 by Yadi Tan, John A. Armstrong, Yang Ke +1 · 3 citations
Medicine · #Cytokine Signaling Pathways and Interactions
paper · doi:10.1073/pnas.67.1.464
openalex publication_date 1970/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
Cycloheximide, at a protein-inhibitory concentration, when given to rabbit kidney cell cultures that had been exposed either to UV-irradiated Newcastle Disease virus or to a complex of polyinosinic and polycytidylic acids (poly I.poly C), enhanced the production of interferon. The enhancement was greater if, in addition to cycloheximide, the cells were also treated with actinomycin D. On the basis of these findings, a mechanism, consisting primarily of the production of a control protein which normally checks interferon production, is postulated for interferons stimulated by these two substances.