Beyond Wolbachia—Can a small molecule control insect reproduction?

2025/10/01 by Robson Kriiger Loterio, Johanna E. Fraser · 1 voice
Agricultural and Biological Sciences · #Insect symbiosis and bacterial influences

paper · pdf · doi:10.1016/j.celrep.2025.116335

Abstract

demonstrate reduced histone acetylation as a key mechanism underpinning Wolbachia's paternal-effect embryonic lethality trait in Drosophila melanogaster. Recapitulation of this trait by inhibiting host histone acetyltransferase activity exposes opportunities for symbiont-independent applied research.

Discussions

• absolutely wild, from the Small Molecules Considered (SMC) branch: "...this work provides another piece in a complex biological puzzle aiming to understand the persistent and pervasive nature of 𝘞𝘰� [bsky, 18 points, 0 comments]

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