2010/04/27 by Kerstin Nagel, Bernd Kastenholz, Frank Gilmer +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Transgenic Plants and Applications #Plant tissue culture and regeneration #Genetically Modified Organisms Research
paper · doi:10.2174/092986610791190282
openalex publication_date 2010/04/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation. Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy