A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000/08/01 by Tanya T Paull, Tanya T. Paull, Emmy P. Rogakou +7 · 11 citations
Biochemistry, Genetics and Molecular Biology · #DNA Repair Mechanisms #Genomics and Chromatin Dynamics #Nuclear Structure and Function

paper · pdf · doi:10.1016/s0960-9822(00)00610-2

crossref issued 2000/08/01 · crossref published 2000/08/01 · crossref published-print 2000/08/01 · openalex publication_date 2000/08/01 · crossref created 2002/07/25 · crossref deposited 2021/05/07 · openalex created_date 2025/10/10 · crossref indexed 2026/07/10 · openalex updated_date 2026/07/22

Citations

• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
• Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Cited by

• MDC1 is a mediator of the mammalian DNA damage checkpoint
• Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break
• Histone H2A variants H2AX and H2AZ
• Genomic Instability in Mice Lacking Histone H2AX
• Phosphorylation of Stem-Loop Binding Protein (SLBP) on Two Threonines Triggers Degradation of SLBP, the Sole Cell Cycle-Regulated Factor Required for Regulation of Histone mRNA Processing, at the End of S Phase
• Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
• NUMB controls p53 tumour suppressor activity
• Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity
• MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
• A single, mild, transient scrotal heat stress causes DNA damage, subfertility and impairs formation of blastocysts in mice
• Histone [wikipedia]