2011/03/20 by Frank M. Sacks, Editorial Board, Chunyu Zheng, Jeffrey S. Cohn, Editorial Board · 3 citations
Medicine · #Lipid metabolism and disorders #Diabetes, Cardiovascular Risks, and Lipoproteins #Cholesterol and Lipid Metabolism
paper · pdf · doi:10.1194/jlr.e015701
openalex publication_date 2011/03/20 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Apolipoprotein C-III (apoC-III) is a protein of 79 amino acids that is synthesized in the liver and to a lesser degree in the intestine (1). In the circulation, apoC-III is a constituent of both apoB- and apoA-I-containing lipoproteins. It is not evenly distributed between these lipoproteins however, with the majority of apoC-III found in the HDL fraction in normolipidemic individuals and on triglyceride-rich lipoproteins in patients with elevated levels of plasma triglyceride (2, 3). Furthermore, some VLDLs, intermediate density lipoproteins (IDLs) and LDLs contain many molecules of apoC-III, whereas others contain none (4).