Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

2009/11/05 by Claire M. Wade, Elena Giulotto, Snævar Sigurðsson +55 · 3 citations
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Genetic diversity and population structure #Genetic Mapping and Diversity in Plants and Animals #Chromosomal and Genetic Variations

paper · doi:10.1126/science.1178158

openalex publication_date 2009/11/05 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/04

Abstract

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

Citations

• Horse Domestication and Conservation Genetics of Przewalski's Horse Inferred from Sex Chromosomal and Autosomal Sequences
• Evolutionary movement of centromeres in horse, donkey, and zebra
• Genome sequence, comparative analysis and haplotype structure of the domestic dog
• Initial sequencing and analysis of the human genome

Cited by

• Ancient genomes revisit the ancestry of domestic and Przewalski’s horses
• Multi-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis
• Horse [wikipedia]