Detecting Gram-negative bacteria

2015/06/11 by Kristen L. Mueller · 1 citation
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Immune Response and Inflammation #Vibrio bacteria research studies #Bacterial Genetics and Biotechnology

paper · doi:10.1126/science.348.6240.1218-o

openalex publication_date 2015/06/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

Innate Immunity Invariant molecules specific to different classes of microbes, but not expressed by eukaryotic cells, alert the immune system to a potential invader. Gaudet et al. identified one such molecule expressed by a variety of Gram-negative bacteria: the monosaccharide heptose-1,7-bisphosphate (HBP) (see the Perspective by Brubaker and Monack). HBP is an intermediate in the synthesis of lipopolysaccharide, a major component of bacterial cell walls. Rather than alerting the immune system through traditional pathogen detection pathways, such as Toll-like receptors, HBP signals through the host protein TIFA (TRAF-interacting protein with forkhead-associated domain), which activates both innate and adaptive immune responses to control the infection. Science , this issue p. [1251][1]; see also p. [1207][2] [1]: /lookup/doi/10.1126/science.aaa4921 [2]: /lookup/doi/10.1126/science.aac5835

Cited by

• Gram stain [wikipedia]

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