1971/01/01 by Robert T. Dorsam, J. Silvio Gutkind, 茂久 関口 +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Cancer, Stress, Anesthesia, and Immune Response #Chemokine receptors and signaling #Mechanisms of cancer metastasis #Neuropeptides and Animal Physiology #Receptor Mechanisms and Signaling
paper · doi:10.1038/nrc2069
openalex publication_date 1971/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/14
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply, invade their surrounding tissues and disseminate to other organs. This Review will address our current understanding of the many roles of GPCRs and their signalling circuitry in tumour progression and metastasis. We will also discuss how interfering with GPCRs might provide unique opportunities for cancer prevention and treatment.