Mammalian G Proteins and Their Cell Type Specific Functions

2005/09/23 by Nina Wettschureck, Stefan Offermanns · 2 citations
Biochemistry, Genetics and Molecular Biology · Nursing · Neuroscience · #Receptor Mechanisms and Signaling #Biochemical Analysis and Sensing Techniques #Neuropeptides and Animal Physiology

paper · doi:10.1152/physrev.00003.2005

openalex publication_date 2005/09/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple subforms of G proteins together with receptors, effectors, and various regulatory proteins represent the components of a highly versatile signal transduction system. G protein-mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. In this review, some of the functions of heterotrimeric G proteins in defined cells and tissues are described.

Citations

• A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse
• The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
• A GNAS1 imprinting defect in pseudohypoparathyroidism type IB
• The Gsα Gene: Predominant Maternal Origin of Transcription in Human Thyroid Gland and Gonads
• A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
• G Protein-Coupled Receptor Rhodopsin: A Prospectus
• Developmental and Hormonally Regulated Messenger Ribonucleic Acid Expression of KiSS-1 and Its Putative Receptor, GPR54, in Rat Hypothalamus and Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide
• Human receptors for sweet and umami taste
• G Protein Modulation of Voltage-Gated Calcium Channels
• G PROTEIN βγ SUBUNITS
• Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor

Cited by

• Influences of Excluded Volume of Molecules on Signaling Processes on the Biomembrane
• G protein-coupled receptor [wikipedia]