2010/06/30 by Johannes Gräff, Kyoko Koshibu, Anne Jouvenceau +2 · 2 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Genetics and Neurodevelopmental Disorders #Neuroscience and Neuropharmacology Research #Neurogenesis and neuroplasticity mechanisms
paper · pdf · doi:10.1101/lm.1766510
openalex publication_date 2010/06/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Gene transcription is essential for the establishment and the maintenance of long-term memory (LTM) and for long-lasting forms of synaptic plasticity. The molecular mechanisms that control gene transcription in neuronal cells are complex and recruit multiple signaling pathways in the cytoplasm and the nucleus. Protein kinases (PKs) and phosphatases (PPs) are important players in these mechanisms. Protein serine/threonine phosphatase 1 (PP1), in particular, was recently shown to be important for transcription-dependent memory by regulating chromatin remodeling. However, the impact of PP1 on gene transcription in adult neurons remains not fully delineated. Here, we demonstrate that the nuclear pool of PP1 is associated with transcriptional events involving molecular components of signaling cascades acting as positive and negative regulators of memory and brain plasticity. The data show that inhibiting this pool selectively in forebrain neurons improves memory performance, enhances long-term potentiation (LTP), and modulates gene transcription. These findings highlight an important role for PP1 in the regulation of gene transcription in LTM and synaptic plasticity in the adult brain.