Functional Translational Readthrough: A Systems Biology Perspective

2016/08/04 by Fabian Schueren, Sven Thoms · 2 citations
Biochemistry, Genetics and Molecular Biology · #Biochemistry #Biology #Biotechnology #CRISPR and Genetic Engineering #Computational biology #Focus (optics) #Gene #Genetics #Identification (biology) #Messenger RNA #Posttranslational modification #RNA Research and Splicing #RNA and protein synthesis mechanisms #Stop codon #Systems biology #Translation (biology) #Translational regulation #Translational research

paper · pdf · doi:10.1371/journal.pgen.1006196

openalex publication_date 2016/08/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Abstract

Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.

Citations

• Domain deletions and substitutions in the modular protein evolution
• Non-canonical translation in RNA viruses
• Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals
• Import of proteins into peroxisomes: piggybacking to a new home away from home

Cited by

• The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code
• Genetic code [wikipedia]

Related

• Translation with frameshifting of ribosome along mRNA transcript
• Expanding the tagging toolbox for visualizing translation live
• In sickness and in health: the importance of translational regulation
• Evolutionary remodeling of non-canonical ORF translation in mammals
• mRNA translation from a unidirectional traffic perspective