2004/10/01 by S M Selkirk · 1 citation
Biochemistry, Genetics and Molecular Biology · #CRISPR and Genetic Engineering #RNA Interference and Gene Delivery #Virus-based gene therapy research
paper · pdf · doi:10.1136/pgmj.2003.017764
openalex publication_date 2004/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Although the field of gene therapy has experienced significant setbacks and limited success, it is one of the most promising and active research fields in medicine. Interest in this therapeutic modality is based on the potential for treatment and cure of some of the most malignant and devastating diseases affecting humans. Over the next decade, the relevance of gene therapy to medical practices will increase and it will become important for physicians to understand the basic principles and strategies that underlie the therapeutic intervention. This report reviews the history, basic strategies, tools, and several current clinical paradigms for application.