1965/11/11 by Gerald Weissmann · 2 citations
Biochemistry, Genetics and Molecular Biology · #Identification and Quantification in Food
paper · doi:10.1056/nejm196511112732006
openalex publication_date 1965/11/11 · openalex created_date 2022/05/12 · openalex updated_date 2026/07/31
LYSOSOMES are a heterogeneous group of cytoplasmic organelles that mediate the digestive and lytic processes of the cell. Yet despite their ubiquitous distribution and their visibility, after appropriate fixation and staining, by light microscopy, it was not until 1955 that de Duve and his associates1 postulated "the lysosome" as the result of biochemical studies of cell fractionation. Since then, these bodies have been identified in most vertebrate cells, such as the liver,2 spleen,3 kidney,4 brain,5 gut,6 thyroid gland,7 leukocytes,8 macrophages,9 pancreas,10 prostate,11 ovary,12 uterus,12 muscle,13 heart,14 synovium,15 skin,16 spinal ganglions17 and bladder.18 They have also been found in invertebrates19 and . . .