Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin

1981/06/01 by R. B. Woodward, Eugene W. Logusch, K. P. Nambiar +7 · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Chemical Synthesis and Analysis #Carbohydrate Chemistry and Synthesis #Synthesis and Reactions of Organic Compounds

paper · doi:10.1021/ja00401a051

openalex publication_date 1981/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/02

Abstract

In the preceding paper' we described the preparation of the
\nkey lactone intermediate la in optically active form. In this paper we report the synthesis of erythromycin (2) from la. In essence,this transformation involves the glycosidation of a suitable derivative of la with L-cladinose and D-desosamine and the generation of the C-9 ketone functionality.

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